{"id":7636,"date":"2018-01-10T14:53:23","date_gmt":"2018-01-10T14:53:23","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/ae-en-new\/?p=7636"},"modified":"2018-01-11T10:40:26","modified_gmt":"2018-01-11T10:40:26","slug":"possible-tooth-decay-treatment-dental-pulp-stem-cells","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/ae-en\/blog\/possible-tooth-decay-treatment-dental-pulp-stem-cells\/","title":{"rendered":"Possible tooth decay treatment with dental pulp stem cells"},"content":{"rendered":"<h3>Research published by two university laboratories in China gives new hope to tooth decay sufferers. It shows that modified dental pulp stem cells could promote dental tissue regeneration.<\/h3>\n<p><!--more--><\/p>\n<p>The research, published in STEM CELLS Translational Medicine, shows that when human dental pulp was modified to over-express\u00a0Platelet-Derived Growth Factor-BB (PDGF-BB), the cells significantly enhanced tissue regeneration.<\/p>\n<p>Although the dental pulp stem cells weren&#8217;t able to repair the tooth directly, this new breakthrough could mean the end of pain and discomfort for those with toothache. Firstly, the authors of the study transduced multipotent, early passage dental pulp stem cells (hDPSCs) with a PDGF-BB expression vector. This generated cells that displayed heightened proliferation and elevated levels of odontogenic marker genes &#8211; which are involved in tooth development. The modified stem cells also attached and spread well on the surface of calcium phosphate cement (CPC) applied for implantation.<\/p>\n<div id=\"page\">\n<div id=\"main\">\n<div id=\"content\" class=\"column\" role=\"main\">\n<div id=\"node-3087\" class=\"node node-article node-promoted view-mode-full clearfix\">\n<div class=\"content\">\n<div class=\"field field-name-body field-type-text-with-summary field-label-hidden\">\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<blockquote><p>PDGF-BB modified cells generated more dentin-like mineralized tissue surrounded by highly vascularized dental pulp-like connective tissue at 12 weeks when compared to unmodified hDPSCs<\/p><\/blockquote>\n<p><cite>&#8211; Zhang, W et al., Shanghai Jiao Tong University\u00a0<\/cite><\/p>\n<p><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sctm.17-0033\/abstract\">Click here to learn more about the results of this dental pulp stem cell study<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"page\">\n<div id=\"main\">\n<div id=\"content\" class=\"column\" role=\"main\">\n<div id=\"node-3087\" class=\"node node-article node-promoted view-mode-full clearfix\">\n<div class=\"content\">\n<div class=\"field field-name-body field-type-text-with-summary field-label-hidden\">\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"helpful-block-content wth-theme-thumbs\" data-title=\"\">\n<ul>\n<li><span class=\"wth-title\">Was this Helpful?<\/span><\/li>\n<li><a data-post=\"7636\" data-post-url=\"https:\/\/futurehealthbiobank.com\/ae-en\/blog\/possible-tooth-decay-treatment-dental-pulp-stem-cells\/\" data-post-title=\"Possible tooth decay treatment with dental pulp stem cells\" data-response=\"1\" href=\"#\" class=\"wth-green-btn icon-thumbs-o-up icon1-thumbs-o-up\">Yes<\/a><a data-response=\"0\" data-post=\"7636\" data-post-url=\"https:\/\/futurehealthbiobank.com\/ae-en\/blog\/possible-tooth-decay-treatment-dental-pulp-stem-cells\/\" data-post-title=\"Possible tooth decay treatment with dental pulp stem cells\" href=\"#\" class=\"wth-red-btn icon-thumbs-o-down icon1-thumbs-o-down\">No<\/a><\/li>\n<\/ul>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Research published by two university laboratories in China gives new hope to tooth decay sufferers. It shows that modified dental pulp stem cells could promote dental tissue regeneration. Was this Helpful? YesNo<\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[220],"tags":[],"class_list":["post-7636","post","type-post","status-publish","format-standard","hentry","category-clinical-updates"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.7 (Yoast SEO v26.7) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Possible tooth decay treatment with dental pulp stem cells - Future Health Biobank ae-en<\/title>\n<meta name=\"description\" content=\"Research published by a university in China gives new hope to tooth decay sufferers, showing that dental pulp stem cells could regenerate dental tissue.\u00a0\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Possible tooth decay treatment with dental pulp stem cells\" \/>\n<meta property=\"og:description\" content=\"Research published by two university laboratories in China gives new hope to tooth decay sufferers. 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