Rezultate premtuese t\u00eb v\u00ebrejtura nga prova m\u00eb e fundit klinike p\u00ebr p\u00ebrdorimin e qelizave staminale n\u00eb trajtimin e epidermolisis bullosa recizive distrofike.<\/p>\n
Ne mor\u00ebm pak koh\u00eb, p\u00ebr t\u00eb biseduar me ekspertin brenda sht\u00ebpis\u00eb son\u00eb; Osama Shaikh, p\u00ebr t\u00eb m\u00ebsuar m\u00eb shum\u00eb rreth p\u00ebrparimeve t\u00eb k\u00ebsaj prove t\u00eb re.<\/p>\n
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Ne kemi par\u00eb disa rezultate mjaft premtuese nga prova m\u00eb e fundit klinike p\u00ebr nj\u00eb terapi t\u00eb re me qeliza staminale p\u00ebr nj\u00eb s\u00ebmundje l\u00ebkure t\u00eb rrall\u00eb dhe disabilituese t\u00eb l\u00ebkur\u00ebs; epidermolisis bullosa recizive distrofike. Trajtimi i cili p\u00ebrfshiu infuzionin e qelizave staminale, rezultoi t\u00eb ishte nj\u00eb leht\u00ebsyues p\u00ebr dhimbjet ndarkoh\u00eb q\u00eb reduktonte gravitetin e problemit t\u00eb l\u00ebkur\u00ebs.<\/p>\n
Epidermolisis bullosa recizive distrofike (RDEB) \u00ebsht\u00eb nj\u00eb s\u00ebmundje l\u00ebkur\u00eb me dhimbje ekstreme; edhe plagosja m\u00eb e vog\u00ebl e l\u00ebkur\u00ebs do t\u00eb \u00e7onte n\u00eb plag\u00eb t\u00eb cilat nuk do t\u00eb sh\u00ebroheshin kurr\u00eb plot\u00ebsisht. N\u00eb mbret\u00ebrin\u00eb e Bashkuar jetojn\u00eb aktualisht rreth 1,000 njer\u00ebz me k\u00ebt\u00eb s\u00ebmundje agresive. L\u00ebkura delikate e shkaktuar prej vragave t\u00eb RDEB, zhvillon kontraktime dhe \u00ebsht\u00eb e prirur t\u00eb shkaktoj\u00eb kacere l\u00ebkur\u00eb q\u00eb shkurtojn\u00eb jet\u00ebn. Fatkeqsisht,n\u00eb dit\u00ebt e sotme nuk ka nj\u00eb kur\u00eb p\u00ebr s\u00ebmundjen RDEB.<\/p>\n
Prova klinike m\u00eb e fundit, e udh\u00ebhequr nga King\u2019s College Lond\u00ebr n\u00eb bashk\u00ebpunim me Great Ormond Street Hospital, rekrutoi 10 f\u00ebmij\u00eb me s\u00ebmundjen RDEB. Secili pjes\u00ebmarr\u00ebs mori 3 infuzione me qeliza staminale mezenkemiale(MSC) nga dhurues pa lidhjes. Ata u monitoruan nga af\u00ebr p\u00ebr nj\u00eb vit pas infuzioneve t\u00eb qelizave staminale.<\/p>\n
Dr Gabriela Petrof nga King\u2019s College Lond\u00ebr, tha: Ne gjet\u00ebm se sh\u00ebrimi i plag\u00ebve u p\u00ebrmir\u00ebsua n\u00eb t\u00eb gjith\u00eb 10 f\u00ebmij\u00ebt dhe l\u00ebkura ishte m\u00eb pak e inflamuar. Mjaft prej f\u00ebmij\u00ebve p\u00ebrmend\u00ebn gjithashtu se l\u00ebkura e tyre ju jepte m\u00eb pak dhimbje dhe t\u00eb kruara, dhe prind\u00ebrit e tyre vun\u00eb re se sa m\u00eb shum\u00eb energjik\u00eb ishin ata<\/p>\n
Profesor John McGrath, gjithashtu, prej King\u2019s College Lond\u00ebr, tha: N\u00eb 25 vjet t\u00eb k\u00ebrkimeve t\u00eb mia mbi RDEB, kjo ishte hera e par\u00eb q\u00eb un\u00eb vura re q\u00eb nj\u00eb trajtim t\u00eb ndryshonte natyr\u00ebn e s\u00ebmundjes. rezultatet jan\u00eb v\u00ebrtet mbres\u00ebl\u00ebn\u00ebse dhe injektimi i qelizave staminale mezenkemiale nuk nxorri probleme sigurie. N\u00eb t\u00eb nj\u00ebjt\u00ebn koh\u00eb, \u00ebsht\u00eb m\u00eb r\u00ebnd\u00ebsi t\u00eb vihet re se kjo nuk \u00ebsht\u00eb nj\u00eb kur\u00eb dhe se p\u00ebrfitimet zbehen pas rreth gjasht\u00eb muajsh<\/p>\n
N\u00eb t\u00ebr\u00ebsi, rezultatet e prov\u00ebs jan\u00eb premtuese. Megjithat\u00eb, nevojitet pun\u00eb e m\u00ebtejshmep\u00ebr t\u00eb kuptuar m\u00eb mir\u00eb mekanizmin q\u00eb p\u00ebrfshihet n\u00eb stimulimin e sh\u00ebrimit t\u00eb plag\u00ebve dhe n\u00eb reduktimin e inflamacionit n\u00eb l\u00ebkur\u00eb. Studime shtes\u00eb do t\u00eb k\u00ebrkohen gjithashtu p\u00ebr t\u00eb konfirmuar efektivitetin e k\u00ebtij trajtimi dhe p\u00ebr t\u00eb p\u00ebrcaktuar doz\u00ebn optimale t\u00eb qelizave p\u00ebr t’u p\u00ebrdorur n\u00eb pacient\u00ebt me RDEB.<\/p>\n