{"id":9009,"date":"2018-05-16T11:16:47","date_gmt":"2018-05-16T10:16:47","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/ba\/?p=9009"},"modified":"2018-05-16T11:16:47","modified_gmt":"2018-05-16T10:16:47","slug":"maticne-celije-krvi-pupcanika-pomazu-pacijentima-oboljelim-od-akutne-mijeloidne-leukemije","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/ba\/blog\/maticne-celije-krvi-pupcanika-pomazu-pacijentima-oboljelim-od-akutne-mijeloidne-leukemije\/","title":{"rendered":"Mati\u010dne \u0107elije krvi pup\u010danika poma\u017eu pacijentima oboljelim od akutne mijeloidne leukemije"},"content":{"rendered":"

Akutna mijeloidna leukemija (AML) je \u010desta vrsta malignog oboljenja kod starijih odraslih osoba. Trenutno se lije\u010di intenzivnom hemoterapijom i oblicima potporne njege koja dovodi do potpune remisije, uklanjanja znakova oboljena kod 40-60% pacijenata. Me\u0111utim, kod ve\u0107ine pacijenata oboljenje se vra\u0107a, rezultiraju\u0107i 5-godi\u0161njom stopom pre\u017eivljavanja od oko 10%.<\/h3>\n

<\/p>\n

Po prvi put, hematopoetske mati\u010dne \u0107elije i progenitorne \u0107elije (HSPCs) iz djelomi\u010dno HLA-podudarnog uzorka krvi pup\u010danika kori\u0161tene su za generiranje “Natural Killer” (NK) \u0107elija. Ove \u0107elije su pokazale da privremeno vra\u0107aju funkciju imunolo\u0161kog sustava kod pacijenata s akutnom mijeloidnom leukemijom i sprije\u010davaju recidive.<\/p>\n

NK \u0107elije izvedene iz HSPC \u0107elija, kori\u0161tene su kod deset starijih pacijenata sa AML nakon \u0161to su primali hemoterapiju. Sljede\u0107ih nekoliko dana, infuzirane NK \u0107elije pokazale su znakove uspje\u0161nog sazrijevanja i uspostavljanja unutar tijela pacijenata. NK \u0107elije su uspje\u0161no pove\u0107ale razinu plazma faktora i pokazatelje normalnih imunolo\u0161kih funkcija. Ovi rezultati daju nadu za kori\u0161tenje mati\u010dnih \u0107elija pup\u010danika u razvoju terapija za lije\u010denje malignih oboljenja.<\/p>\n

Klini\u010dko ispitivanje provedeno je od strane nau\u010dnika Ameri\u010dke udruge za istra\u017eivanje raka i objavljeno u martu 2017. Obe\u0107avaju\u0107i nalazi sugeriraju da se HSPC-NK \u0107elije mogu koristiti u budu\u0107nosti kao “off-the-shelf” oblik imunoterapije za ljude koji \u017eive s AML-om.<\/p>\n

Iako je gore opisani pristup fantasti\u010dan korak naprijed u produ\u017eenju \u017eivota pacijenata oboljelih od AML-a, jo\u0161 uvijek treba dalje raditi u vezi mogu\u0107nosti ovakvog pristupa da ubije tumorske \u0107elije.<\/p>\n

Reference:\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28280089<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Akutna mijeloidna leukemija (AML) je \u010desta vrsta malignog oboljenja kod starijih odraslih osoba. Trenutno se lije\u010di intenzivnom hemoterapijom i oblicima potporne njege koja dovodi do potpune remisije, uklanjanja znakova oboljena kod 40-60% pacijenata. Me\u0111utim, kod ve\u0107ine pacijenata oboljenje se vra\u0107a, rezultiraju\u0107i 5-godi\u0161njom stopom pre\u017eivljavanja od oko 10%.<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[218],"tags":[],"class_list":["post-9009","post","type-post","status-publish","format-standard","hentry","category-klinicko-azuriranje"],"acf":[],"yoast_head":"\nMati\u010dne \u0107elije krvi pup\u010danika poma\u017eu pacijentima oboljelim od akutne mijeloidne leukemije | Future Health Biobank<\/title>\n<meta name=\"description\" content=\"Po prvi put, hematopoetske mati\u010dne \u0107elije i progenitorne \u0107elije (HSPCs) iz djelomi\u010dno HLA-podudarnog uzorka krvi pup\u010danika kori\u0161tene su za generiranje "Natural Killer" (NK) \u0107elija. 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