{"id":9567,"date":"2018-11-21T10:26:56","date_gmt":"2018-11-21T10:26:56","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/ba\/?p=9567"},"modified":"2018-11-21T10:26:56","modified_gmt":"2018-11-21T10:26:56","slug":"otkriven-novi-nacin-multipliciranja-maticnih-celija-krvi-pupcanika","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/ba\/blog\/otkriven-novi-nacin-multipliciranja-maticnih-celija-krvi-pupcanika\/","title":{"rendered":"Otkriven novi na\u010din multipliciranja mati\u010dnih \u0107elija krvi pup\u010danika"},"content":{"rendered":"

Istra\u017eiva\u010di Instituta za medicinska istra\u017eivanja Stowers prona\u0161li su drugi na\u010din ekspanzije\/multipliciranja krvotvornih, odraslih mati\u010dnih \u0107elija iz krvi pup\u010danika. Otkri\u0107e pove\u0107ava potencijal jednog uzorka mati\u010dnih \u0107elija u lije\u010denju ve\u0107eg broja medicinskih stanja.<\/h3>\n

<\/p>\n

U ovom istra\u017eivanju nau\u010dnici su bili usmjereni na protein koji utje\u010de na sposobnost hematopoetskih mati\u010dnih \u0107elija da se samoobnavljaju. Kada je funkcija ovog proteina – zvanog Ythdf2 – privremeno smanjena, otkrivena je pove\u0107ana ekspanzija hematopoetskih mati\u010dnih \u0107elija. Nau\u010dnici su tako\u0111er primijetili da smanjenje razine Ythdf2 nije promijenilo tipove \u0107elija koje su proizvedene.<\/p>\n

Trenutno, mati\u010dne \u0107elije krvi pup\u010danika mogu se koristiti za lije\u010denje poreme\u0107aja imunolo\u0161kog sistema, poreme\u0107aja krvi, leukemije i odre\u0111enih vrsta raka. Ova stanja se tako\u0111er mogu lije\u010diti kori\u0161tenjem mati\u010dnih \u0107elija ko\u0161tane sr\u017ei, isto kao i sa \u0107elijma iz krvi pup\u010danika, ali je podudarnog donora ko\u0161tane sr\u017ei te\u017ee prona\u0107i. U Velikoj Britaniji samo 69% pacijenata prona\u0111e donora ko\u0161tane sr\u017ei sa prihvatljivim podudaranjem[1].<\/p>\n

Za usporedbu, odrasle mati\u010dne \u0107elije iz pup\u010dane vrpce nude ve\u0107u vjerovatnost za podudaranje za vi\u0161e ljudi. To je zato \u0161to postoji manje zahtjeva za kompatibilnost\/podudaranje nego \u0161to je to slu\u010daj sa mati\u010dnim \u0107elijama ko\u0161tane sr\u017ei. Ako istra\u017eivanja na Institutu Stowers<\/strong><\/a> budu napredovala, upotreba ovih visoko u\u010dinkovitih mati\u010dnih \u0107elija mo\u017ee i\u0107i prema lije\u010denju vi\u0161e oboljena odraslih.<\/p>\n

Dr. Zhenrui Li iz Medicinskog centra Sveu\u010dili\u0161ta u Kansasu primijetio je da je njihov istra\u017eiva\u010dki pristup pomogao izbje\u0107i trajne mutacije vezane uz DNK, \u0161to bi moglo dovesti do razvoja leukemije ili stanica raka. Nadamo se da bi ova nova tehnika ekspanzije za mati\u010dne \u0107elije krvi pup\u010danika mogla biti primijenjena i na druge vrste mati\u010dnih \u0107elija odraslih.]<\/p>\n

Ovaj rad predstavlja put naprijed demonstriraju\u0107i sposobnost pouzdane ekspanzije mati\u010dnih \u0107elija krvi pup\u010danika u laboratoriju bez terminalne diferencijacije \u0107elija u zrelije i relativno kratkotrajne \u017eivu\u0107e krvne \u0107elije…Pomenuti nalazi predstavljaju veliki napredak u ovom polju i imaju zna\u010dajni potencijal za pobolj\u0161anje ishoda lije\u010denje hiljada oboljele djece i odraslih koji se podvrgavaju transplantaciji krvi pup\u010danika svake godine.<\/p>\n

Joseph McGuirk, MD, Medicinski centae Sveu\u010dili\u0161ta u Kansasu<\/cite><\/p>\n

Reference:
\n[1]\u00a0https:\/\/www.anthonynolan.org\/facts-and-stats<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Istra\u017eiva\u010di Instituta za medicinska istra\u017eivanja Stowers prona\u0161li su drugi na\u010din ekspanzije\/multipliciranja krvotvornih, odraslih mati\u010dnih \u0107elija iz krvi pup\u010danika. Otkri\u0107e pove\u0107ava potencijal jednog uzorka mati\u010dnih \u0107elija u lije\u010denju ve\u0107eg broja medicinskih stanja.<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[218],"tags":[],"class_list":["post-9567","post","type-post","status-publish","format-standard","hentry","category-klinicko-azuriranje"],"acf":[],"yoast_head":"\nOtkriven novi na\u010din multipliciranja mati\u010dnih \u0107elija krvi pup\u010danika | Future Health Biobank<\/title>\n<meta name=\"description\" content=\"Istra\u017eiva\u010di Instituta za medicinska istra\u017eivanja Stowers prona\u0161li su drugi na\u010din ekspanzije\/multipliciranja krvotvornih, odraslih mati\u010dnih \u0107elija iz krvi pup\u010danika. 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