{"id":9620,"date":"2019-05-07T12:38:45","date_gmt":"2019-05-07T11:38:45","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/ba\/?p=9620"},"modified":"2019-05-07T12:38:45","modified_gmt":"2019-05-07T11:38:45","slug":"maticne-celije-ucinkovito-tretiraju-artritis-koljena","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/ba\/blog\/maticne-celije-ucinkovito-tretiraju-artritis-koljena\/","title":{"rendered":"Mati\u010dne \u0107elije u\u010dinkovito tretiraju artritis koljena"},"content":{"rendered":"

Klini\u010dko ispitivanje u Torontu u Kanadi pokazalo je da jedna injekcija MSC (mezenhimalnih mati\u010dnih \u0107elija) mo\u017ee za sigurno smanjiti bol i pobolj\u0161ati kvalitet \u017eivota kod bolesnika sa kasnim stadijem osteoartritisa koljena.<\/h3>\n

<\/p>\n

Kako starimo sve \u0107elije u na\u0161em tijelu po\u010dinju polako da propadaju, samim time mogu\u0107nost pojave osteoartritisa se pove\u0107ava. Naj\u010de\u0161\u0107i oblik osteoartritisa u Velikoj Britaniji je artritis, koji poga\u0111a oko 10 milijuna ljudi i uzrokuje bolne i uko\u010dene zglobove. Iako je vjerovatno\u0107a za ovu bolest u\u010destalija kod starijih pacijenata, artritis se mo\u017ee javiti u bilo kojoj \u017eivotnoj dobi, uklju\u010duju\u0107i i djetinjstvo.<\/p>\n

MSC koje su izolovane iz krvi i tkiva pup\u010dane vrpce ili iz ko\u0161tane sr\u017ei mogu se ubrizgati u ljudsku hrskavicu – vezivno tkivo koje poma\u017ee pri kretanju kostiju. U nedavno objavljenom klini\u010dkom ispitivanju dokazano je da ove specijalizirane mati\u010dne \u0107elije poma\u017eu u lije\u010denju osteoartritisa.<\/p>\n

Klini\u010dko ispitivanje, objavljeno u Aprilu 2019. godine, uklju\u010divalo je ubrizgavanje MSC \u0107elija u zahva\u0107eno podru\u010dje zglobova, da bi podstaklo obnavljanje funkcije \u0107elija hrskavice koje su postale manje aktivne ili su prestale zajedno funkcionirati. Rezultati su pokazali pobolj\u0161anu u\u010dinkovitost vezivnog tkiva, smanjenu bol povezanu sa osteoartritisom kao i bolji kvalitet \u017eivota kod tretiranih pacijenata.<\/p>\n

Na\u0161 je cilj bio testirati sigurnost te posti\u0107i bolje razumjevanje u na\u010dinu doziranja, mehanizmima djelovanja i selekciji donora MSC \u0107elija<\/p><\/blockquote>\n

– Dr. Viswanathan, Krembil Research Institut, Univerzitet Health Network, Toronto<\/cite><\/p>\n

Ukupno 12 pacijenata sudjelovalo je u ovom ispitivanju, u dobi od 45 do 65 godina sa umjerenim osteoartritisom koljena. Pacijenti su bili podijeljeni u tri skupine, od kojih je svaka primala druga\u010diju dozu MSC-a.<\/p>\n

12 mjeseci kasnije, istra\u017eiva\u010di su uo\u010dili zna\u010dajna pobolj\u0161anja kod bolesnika. Studija je tako\u0111er zaklju\u010dila da su MSC siguran oblik lije\u010denja u razli\u010ditim dozama, te da je u\u010dinkovitost lije\u010denja ovisila o dozi.<\/p>\n

MSC \u0107elije se mogu izolirati iz ko\u0161tane sr\u017ei (naj\u010de\u0161\u0107e iz zdjelice), tkiva pup\u010dane vrpce pohranjenim nakon ro\u0111enja djeteta, ili iz pulpe mlije\u010dnog zuba. Future Health Biobank specijaliziran je za uzimanje i pohranjivanje mati\u010dnih \u0107elija iz krvi i tkiva pup\u010dane vrpce kao i iz zubne pulpe mlije\u010dnog zuba kod djece. Posjedujemo preko 150.000 uzoraka pohranjenih za porodice \u0161irom svijeta, te smo izdali vi\u0161e od 100 uzoraka za tretmane koji utje\u010du na pobolj\u0161anje kvaliteta \u017eivota, poput lije\u010denja osteoartritisa. \u010cuvanjem mati\u010dnih \u0107elija va\u0161eg djeteta od ro\u0111enja ili rane dobi osiguravate kvalitetiniji i uspje\u0161nii ishod mogu\u0107ih terapija u budu\u0107nosti.<\/p>\n

Reference:
\nBenzinga. \u201cClinical Trial Shows Promise of Stem Cells in Offering Safe, Effective Relief from Arthritic Knees | Benzinga.\u201d Benzinga, Benzinga, 9 Apr. 2019,\u00a0www.benzinga.com\/pressreleases\/19\/04\/r13509497\/clinical-trial-shows-promise-of-stem-cells-in-offering-safe-effective-relief-from-arthritic-knees<\/a>. Accessed 10 Apr. 2019.<\/p>\n

Chahal, Jaskarndip, et al. \u201cBone Marrow Mesenchymal Stromal Cells in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation.\u201d STEM CELLS Translational Medicine, 9 Apr. 2019, 10.1002\/sctm.18-0183. Accessed 10 Apr. 2019.<\/p>\n","protected":false},"excerpt":{"rendered":"

Klini\u010dko ispitivanje u Torontu u Kanadi pokazalo je da jedna injekcija MSC (mezenhimalnih mati\u010dnih \u0107elija) mo\u017ee za sigurno smanjiti bol i pobolj\u0161ati kvalitet \u017eivota kod bolesnika sa kasnim stadijem osteoartritisa koljena.<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[218],"tags":[],"class_list":["post-9620","post","type-post","status-publish","format-standard","hentry","category-klinicko-azuriranje"],"acf":[],"yoast_head":"\nMati\u010dne \u0107elije u\u010dinkovito tretiraju artritis koljena | Future Health Biobank<\/title>\n<meta name=\"description\" content=\"Klini\u010dko ispitivanje u Torontu u Kanadi pokazalo je da jedna injekcija MSC (mezenhimalnih mati\u010dnih \u0107elija) mo\u017ee za sigurno smanjiti bol i pobolj\u0161ati kvalitet \u017eivota kod bolesnika sa kasnim stadijem 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