{"id":9621,"date":"2019-05-09T09:14:45","date_gmt":"2019-05-09T08:14:45","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/ba\/?p=9621"},"modified":"2019-05-09T09:14:45","modified_gmt":"2019-05-09T08:14:45","slug":"da-li-maticne-celije-pupcanika-mogu-pomoci-oboljelima-od-lupusa","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/ba\/blog\/da-li-maticne-celije-pupcanika-mogu-pomoci-oboljelima-od-lupusa\/","title":{"rendered":"Da li mati\u010dne \u0107elije pup\u010danika mogu pomo\u0107i oboljelima od lupusa?"},"content":{"rendered":"<h3>Prva faza klini\u010dkog ispitivanja ispitala je u\u010dinak mezenhimalnih mati\u010dnih \u0107elija (MSC) dobivenih iz pup\u010dane vrpce na imunolo\u0161ki sistem pacijenata sa lupusom. Iako se radilo o manjoj studiji, pozitivni rezultati su zabilje\u017eeni 24 sedmice nakon samog tretmana.<\/h3>\n<p><!--more--><\/p>\n<p>Tokom ispitivanja vr\u0161enog na Medicinskom Univerzitetu Ju\u017ena Karolina, \u0161est pacijenata sa refraktornim sistemskim eritemskim lupusom (SLE) primilo je injekciju MSC \u0107elija iz pup\u010dane vrpce. Nakon injekcije, nau\u010dnici su analizirali u\u010dinak MSC \u0107elija na imunolo\u0161ki sistem tretiranih pacijenata. Studija je bila specifi\u010dno fokusirana na efekat T-\u0107elija i B-\u0107elija na funkciju imunolo\u0161kog sistema kod pacijenata oboljelih od lupusa.<\/p>\n<p>24 sedmice nakon tretmana, pokazalo se da MSC \u0107elije poma\u017eu u regulaciji aktivnosti B-\u0107elija i autoimunosti. Mati\u010dne \u0107elije su zna\u010dajno smanjile broj abnormalnih memorijskih B-\u0107elija i pove\u0107ale broj nereaktivnih B-\u0107elija kod \u010detiri od \u0161est tretiranih pacijenata. Kod dva pacijenta, tretman mati\u010dnim \u0107elijama djelovao je na blago pove\u0107anje T-\u0107elija.<\/p>\n<p>Mezenhimalne mati\u010dne \u0107elije (MSC) nalaze se u tkivu pup\u010dane vrpce. Ove \u0107elije mogu se razmno\u017eavati u obliku hrskavice, kostiju i masti. Prva faza ovog klini\u010dkog ispitivanja ukazuje na to da bi terapija koja uklju\u010duje ubrizgavanje MSC \u0107elija mogla pobolj\u0161ati tretman lije\u010denja lupusa koji se ina\u010de jako te\u0161ko lije\u010di. Da bi se dobijeni rezultati dalje ispitali i potvrdili pokrenuta je druga faza ispitivanja ove klini\u010dke studije.<\/p>\n<p>U drugoj fazi klini\u010dke studije, nau\u010dnici \u0107e provesti dvostruki slijepi (eng. double blind), placebo-kontrolirani eksperiment &#8211; uz standardnu terapiju za lupus &#8211; kod 81 odrasle osobe. Studija \u0107e obuhvatiti nasumi\u010dno odabrane pacijente koji \u0107e primiti jednu do dvije MSC infuzije \u0107elija ili placebo. Da bi potvrdli u\u010dinkovitost ove terapije, nau\u010dnici \u0107e pratiti smanjenje aktivnosti bolesti od \u010detiri ili vi\u0161e stupnjeva prema indeksu aktivnosti sistematske eritemske bolesti lupusa (SLEDAI), kao i parametre kao \u0161to su procenat \u0161irenja bolesti, umor, bol i depresiju.<\/p>\n<p>Nau\u010dnici se nadaju da \u0107e se nakon zavr\u0161etka druge faze klini\u010dke studije razumjeti efikasnost i sigurnost kori\u0161tenja MSC iz pup\u010dane vrpce za lije\u010denje Lupusa u budu\u0107nosti.<\/p>\n<p>Reference:<br \/>\n<a href=\"https:\/\/lupusnewstoday.com\/2018\/11\/12\/mesenchymal-stem-cell-treatment-benefits-lupus-patients-in-phase-1-trial-new-study-opening\/\">https:\/\/lupusnewstoday.com\/<\/a><br \/>\n<a href=\"https:\/\/acrabstracts.org\/abstract\/marked-immune-cell-subset-changes-in-refractory-lupus-patients-in-a-phase-i-trial-of-allogenic-mesenchymal-stem-cells\/\">https:\/\/acrabstracts.org\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prva faza klini\u010dkog ispitivanja ispitala je u\u010dinak mezenhimalnih mati\u010dnih \u0107elija (MSC) dobivenih iz pup\u010dane vrpce na imunolo\u0161ki sistem pacijenata sa lupusom. Iako se radilo o manjoj studiji, pozitivni rezultati su zabilje\u017eeni 24 sedmice nakon samog tretmana.<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[218],"tags":[],"class_list":["post-9621","post","type-post","status-publish","format-standard","hentry","category-klinicko-azuriranje"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.7 (Yoast SEO v26.7) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Da li mati\u010dne \u0107elije pup\u010danika mogu pomo\u0107i oboljelima od lupusa? | Future Health Biobank<\/title>\n<meta name=\"description\" content=\"Prva faza klini\u010dkog ispitivanja ispitala je u\u010dinak mezenhimalnih mati\u010dnih \u0107elija (MSC) dobivenih iz pup\u010dane vrpce na imunolo\u0161ki sistem pacijenata sa lupusom. 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