Bags vs vials

As an industry leader we were always striving to provide our clients with the most comprehensive service. As technology and science evolves so do our methods ensuring our clients receive only the best quality service now and in the future!

There are three ways to store cord blood samples when cryo-preserving them. One large bag, vials and cryo-bags.

Our dual compartment cryo-bags are AABB & HTA approved.

These special bags were produced to provide the most secure method of storage possible, cryo-bags minimise risk of contamination, deterioration and allow for minor samples to be removed for testing without impacting on the central sample. This method of storage also allows for multiple treatments if the bag has separate chambers. Our dual compartment cryo-bags are AABB & HTA approved. Cryo-bags can be fully sealed and vacuum packed into protective wrap to ensure no risk of contamination during freezing. Twist-off caps on vials cannot offer this level of protection.

Vials have been used as a method of storage for many years, it is widely recognised to have been superseded by cryo-bags though some banks still offer vials as a storage option as it will allow clients to store as many vials as they wish. Though this could appear beneficial in theory, many samples once split are then so small they would not be sufficient for any treatment. Vials also do not provide a ‘closed’ system as cry-bags do when processing and there is a far higher risk of contamination. Historically vials can also be unstable in storage and result in leakage rendering the sample unusable. Doctors may also have concerns where several of these small vials need to be re-combined to provide a large enough sample for treatment, in case of further risk of cross contamination or accident.

In the case where whole blood is stored, these samples will be stored in one large bag due to the size of the sample, this can be far harder to freeze stably and does not allow for multiple uses.

AABB (American Association of Blood Banks)

Specially designed bags intended for cryostorage have also been developed. These bags cost more and may occupy a larger amount of freezer space than vials. One advantage of using bags is that they render a more “closed” rather than an “open” system, thereby reducing the risk of accidental contamination. Another advantage to the bag system is that it permits the unit to have integral segments of tubing. AABB requires that integral segments be attached to cord blood units for subsequent testing.’

(Ref link: http://www.aabb.org/sa/facilities/celltherapy/Pages/cordbloodfaqs.aspx#5)

Dr Joanne Kurtzberg

‘Banks should store cord blood units in cryopreservation bags (freezing bags) with attached segments for identity, potency, and other future testing’

(Ref link: https://parentsguidecordblood.org/en/news/dr-joanne-kurtzbergs-vision-harmonization-standards-usa-cord-blood-banks)