{"id":9983,"date":"2019-05-23T14:54:02","date_gmt":"2019-05-23T12:54:02","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/ca-en\/?p=9983"},"modified":"2019-12-30T12:12:57","modified_gmt":"2019-12-30T11:12:57","slug":"breakthrough-therapy-designed-for-periodontitis-sufferers","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/ca-en\/blog\/breakthrough-therapy-designed-for-periodontitis-sufferers\/","title":{"rendered":"Breakthrough therapy designed for periodontitis sufferers"},"content":{"rendered":"

Periodontitis is a painful and destructive dental disease caused by bacteria that induce inflammation, leading to the loss of gums surrounding teeth. As one of the most common dental diseases affecting a large number of the population, researchers have designed a new stem cell-based therapy to treat it.<\/h3>\n

<\/p>\n

Until now, periodontitis is treated with infection-fighting methods and with patients\u2019 Mesenchymal Stem Cells (MSCs) to regenerate the tissue around teeth. However, the success of autologous cells depends on the patient\u2019s age and the tissue quality.<\/p>\n

This new therapy, proposed by Tohoku University Graduate School of Dentistry in Japan, claims to use a safe, effective and cheaper regenerative method. It involves injecting allogeneic MSCs from a healthy donor into the affected one\u2019s defected dental tissue. The cells used for the therapy are called Adipose Derived Mesenchymal Progenitor Stem Cells (ADMPC) and are isolated from the adipose tissue of healthy patients.<\/p>\n

The use of cell-based therapies is a promising approach to treat human disease. This kind of treatment paradigm is important because commercially available stem cells that represent a cell-based therapy specifically developed to treat periodontal tissue regeneration will reduce time and cost while improving quality assurance,<\/p><\/blockquote>\n

– Masahiro Saito, PhD, Division of Operative Dentistry at Tohoku University Graduate School of Dentistry<\/cite><\/p>\n

Our study demonstrates that ADMPCs appear to be safe and not triggering an immune response in allogeneic settings, and as such it explores the potential use of allogeneic MSCs for tissue regeneration. The study is a powerful first step towards further development of stem cell-based therapy for the treatment of periodontal disease<\/p><\/blockquote>\n

– Professor Saito, Division of Operative Dentistry, Tohoku University Graduate School of Dentistry<\/cite><\/p>\n

This study has been completed in minipig models, but the next step for the researchers is to perform a human clinical trial on periodontitis patients. It\u2019s hoped that the trial will deliver a new therapy for periodontal tissue regeneration.<\/p>\n

Allogenic treatment options can be available for patients whose age doesn\u2019t allow for stem cell expansion. However, it\u2019s highly recommended to storage dental pulp stem cells<\/a> from a milk tooth when young. Young dental pulp stem cells have a greater expansion potential in future therapies.<\/p>\n

Reference:
\nwww.ncbi.nlm.nih.gov\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Periodontitis is a painful and destructive dental disease caused by bacteria that induce inflammation, leading to the loss of gums surrounding teeth. As one of the most common dental diseases affecting a large number of the population, researchers have designed a new stem cell-based therapy to treat it.<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[218],"tags":[],"class_list":["post-9983","post","type-post","status-publish","format-standard","hentry","category-clinical-update"],"acf":[],"yoast_head":"\nBreakthrough therapy designed for periodontitis sufferers | Future Health Biobank<\/title>\n<meta name=\"description\" content=\"Periodontitis is a painful and destructive dental disease caused by bacteria that induce inflammation, leading to the loss of gums surrounding teeth. 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