{"id":9836,"date":"2020-07-20T12:20:45","date_gmt":"2020-07-20T11:20:45","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/cy-en\/?p=9836"},"modified":"2020-07-20T12:22:42","modified_gmt":"2020-07-20T11:22:42","slug":"results-revealed-from-duke-universitys-autism-study","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/","title":{"rendered":"Results revealed from Duke University\u2019s autism study"},"content":{"rendered":"

Back in 2017, an initial study began to investigate whether infusions of cord blood can improve the symptoms of autism spectrum disorder (ASD) in young children. Following Phase I and Phase II trials, the results were revealed in the Journal of Pediatrics<\/a> in June 2020.<\/h3>\n

<\/p>\n

The initial Phase I study was carried out on 25 autistic children, aged 2-6. It concluded that approximately 70% of the children showed improvements in one or more core symptoms of autism. The randomised, placebo-controlled Phase II trial, led by Drs. Joanne Kurtzberg and Geraldine Dawson, was designed to confirm these findings by evaluating the effects of autologous and allogenic cord blood on 180 children.<\/p>\n

The children taking part ranged from 2-7 years of age and all had confirmed cases of autism with no known genetic cause. Based on previous results, the children with a non-verbal IQ >70 showed the most improvement after an infusion of autologous cord blood. Therefore, attempts were made to only include children with nonverbal IQ>70.<\/p>\n

The Phase II study involved giving 60 patients autologous cord blood, 60 allogeneic cord blood and 60 a placebo. The children who received autologous cord blood had to have 25 million cells per kg of the child\u2019s weight. Those with less received cord blood from an HLA matching unrelated donor.<\/p>\n

Key findings
\n\u2022 Throughout this final study, no severe adverse effects were observed
\n\u2022 On the Socialization Scale<\/a>, no benefits of cord blood over placebo were found however, this analysis was flawed because only 101 of the 180 children enrolled on the study had a non-verbal IQ >70. The minimum needed was 143 children.
\n\u2022 In the cord blood group, significant improvements were noticed in children aged 4-7 with a non-verbal IG higher than 70
\n\u2022 In most of the measures, there were no advantages of allogeneic or autologous cord blood identified. However, on the Clinical Global Impression-Improvement scale<\/a>, only children receiving allogeneic cord blood showed improvement compared to the placebo
\n\u2022 In the study, allogenic cord blood was given at a higher dose than autologous cord blood, meaning that it wasn\u2019t possible to know whether this advantage was due to cell source or increased dose<\/p>\n

In conclusion, these results demonstrate encouraging news for children aged 4-7 with a non-verbal IQ >70. Particularly, improvements were seen in communication, eye tracking and EEG brain scans.<\/p>\n

Based on lessons learned from this study, Dr. Joanne Kurtzberg recently opened a Phase II clinical trial investigating cord tissue mesenchymal stromal cells (MSCs) to treat autism. You can find out more about it here<\/a>.<\/p>\n

Reference:
\nparentsguidecordblood.org\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Back in 2017, an initial study began to investigate whether infusions of cord blood can improve the symptoms of autism spectrum disorder (ASD) in young children. Following Phase I and Phase II trials, the results were revealed in the Journal of Pediatrics in June 2020.<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[220],"tags":[],"class_list":["post-9836","post","type-post","status-publish","format-standard","hentry","category-clinical-updates"],"acf":[],"yoast_head":"\nResults revealed from Duke University\u2019s autism study | Future Health Biobank<\/title>\n<meta name=\"description\" content=\"Back in 2017, an initial study began to investigate whether infusions of cord blood can improve the symptoms of autism spectrum disorder (ASD) in young children. Following Phase I and Phase II trials, the results were revealed in the Journal of Pediatrics in June 2020.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Results revealed from Duke University\u2019s autism study\" \/>\n<meta property=\"og:description\" content=\"Back in 2017, an initial study began to investigate whether infusions of cord blood can improve the symptoms of autism spectrum disorder (ASD) in young\" \/>\n<meta property=\"og:url\" content=\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Future Health Biobank Cyprus English\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-20T11:20:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-20T11:22:42+00:00\" \/>\n<meta name=\"author\" content=\"jwhybrow\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"jwhybrow\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/\"},\"author\":{\"name\":\"jwhybrow\",\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/#\/schema\/person\/7232eecb00f5f56f8f268c5ff3db6719\"},\"headline\":\"Results revealed from Duke University\u2019s autism study\",\"datePublished\":\"2020-07-20T11:20:45+00:00\",\"dateModified\":\"2020-07-20T11:22:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/\"},\"wordCount\":420,\"commentCount\":0,\"articleSection\":[\"Clinical updates\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/\",\"url\":\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/\",\"name\":\"Results revealed from Duke University\u2019s autism study | Future Health Biobank\",\"isPartOf\":{\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/#website\"},\"datePublished\":\"2020-07-20T11:20:45+00:00\",\"dateModified\":\"2020-07-20T11:22:42+00:00\",\"author\":{\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/#\/schema\/person\/7232eecb00f5f56f8f268c5ff3db6719\"},\"description\":\"Back in 2017, an initial study began to investigate whether infusions of cord blood can improve the symptoms of autism spectrum disorder (ASD) in young children. Following Phase I and Phase II trials, the results were revealed in the Journal of Pediatrics in June 2020.\",\"breadcrumb\":{\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/futurehealthbiobank.com\/cy-en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Results revealed from Duke University\u2019s autism study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/#website\",\"url\":\"https:\/\/futurehealthbiobank.com\/cy-en\/\",\"name\":\"Future Health Biobank Cyprus English\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/futurehealthbiobank.com\/cy-en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/#\/schema\/person\/7232eecb00f5f56f8f268c5ff3db6719\",\"name\":\"jwhybrow\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/futurehealthbiobank.com\/cy-en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c9af53d69103cbfe6f956d3ca06fe15f77fe26760b48a18012d4a05637201dad?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c9af53d69103cbfe6f956d3ca06fe15f77fe26760b48a18012d4a05637201dad?s=96&d=mm&r=g\",\"caption\":\"jwhybrow\"},\"url\":\"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/author\/jwhybrow\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Results revealed from Duke University\u2019s autism study | Future Health Biobank","description":"Back in 2017, an initial study began to investigate whether infusions of cord blood can improve the symptoms of autism spectrum disorder (ASD) in young children. Following Phase I and Phase II trials, the results were revealed in the Journal of Pediatrics in June 2020.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/","og_locale":"en_GB","og_type":"article","og_title":"Results revealed from Duke University\u2019s autism study","og_description":"Back in 2017, an initial study began to investigate whether infusions of cord blood can improve the symptoms of autism spectrum disorder (ASD) in young","og_url":"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/","og_site_name":"Future Health Biobank Cyprus English","article_published_time":"2020-07-20T11:20:45+00:00","article_modified_time":"2020-07-20T11:22:42+00:00","author":"jwhybrow","twitter_card":"summary_large_image","twitter_misc":{"Written by":"jwhybrow","Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/#article","isPartOf":{"@id":"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/"},"author":{"name":"jwhybrow","@id":"https:\/\/futurehealthbiobank.com\/cy-en\/#\/schema\/person\/7232eecb00f5f56f8f268c5ff3db6719"},"headline":"Results revealed from Duke University\u2019s autism study","datePublished":"2020-07-20T11:20:45+00:00","dateModified":"2020-07-20T11:22:42+00:00","mainEntityOfPage":{"@id":"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/"},"wordCount":420,"commentCount":0,"articleSection":["Clinical updates"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/","url":"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/","name":"Results revealed from Duke University\u2019s autism study | Future Health Biobank","isPartOf":{"@id":"https:\/\/futurehealthbiobank.com\/cy-en\/#website"},"datePublished":"2020-07-20T11:20:45+00:00","dateModified":"2020-07-20T11:22:42+00:00","author":{"@id":"https:\/\/futurehealthbiobank.com\/cy-en\/#\/schema\/person\/7232eecb00f5f56f8f268c5ff3db6719"},"description":"Back in 2017, an initial study began to investigate whether infusions of cord blood can improve the symptoms of autism spectrum disorder (ASD) in young children. Following Phase I and Phase II trials, the results were revealed in the Journal of Pediatrics in June 2020.","breadcrumb":{"@id":"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/results-revealed-from-duke-universitys-autism-study\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/futurehealthbiobank.com\/cy-en\/"},{"@type":"ListItem","position":2,"name":"Results revealed from Duke University\u2019s autism study"}]},{"@type":"WebSite","@id":"https:\/\/futurehealthbiobank.com\/cy-en\/#website","url":"https:\/\/futurehealthbiobank.com\/cy-en\/","name":"Future Health Biobank Cyprus English","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/futurehealthbiobank.com\/cy-en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/futurehealthbiobank.com\/cy-en\/#\/schema\/person\/7232eecb00f5f56f8f268c5ff3db6719","name":"jwhybrow","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/futurehealthbiobank.com\/cy-en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c9af53d69103cbfe6f956d3ca06fe15f77fe26760b48a18012d4a05637201dad?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c9af53d69103cbfe6f956d3ca06fe15f77fe26760b48a18012d4a05637201dad?s=96&d=mm&r=g","caption":"jwhybrow"},"url":"https:\/\/futurehealthbiobank.com\/cy-en\/blog\/author\/jwhybrow\/"}]}},"_links":{"self":[{"href":"https:\/\/futurehealthbiobank.com\/cy-en\/wp-json\/wp\/v2\/posts\/9836","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/futurehealthbiobank.com\/cy-en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/futurehealthbiobank.com\/cy-en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/futurehealthbiobank.com\/cy-en\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/futurehealthbiobank.com\/cy-en\/wp-json\/wp\/v2\/comments?post=9836"}],"version-history":[{"count":0,"href":"https:\/\/futurehealthbiobank.com\/cy-en\/wp-json\/wp\/v2\/posts\/9836\/revisions"}],"wp:attachment":[{"href":"https:\/\/futurehealthbiobank.com\/cy-en\/wp-json\/wp\/v2\/media?parent=9836"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/futurehealthbiobank.com\/cy-en\/wp-json\/wp\/v2\/categories?post=9836"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/futurehealthbiobank.com\/cy-en\/wp-json\/wp\/v2\/tags?post=9836"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}