{"id":32275,"date":"2023-08-21T09:33:24","date_gmt":"2023-08-21T08:33:24","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/ee\/?p=32275"},"modified":"2023-08-21T09:33:24","modified_gmt":"2023-08-21T08:33:24","slug":"tuvirakud-sudamepuudulikkuse-ravis","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/ee\/2023\/08\/21\/tuvirakud-sudamepuudulikkuse-ravis\/","title":{"rendered":"T\u00fcvirakud s\u00fcdamepuudulikkuse ravis"},"content":{"rendered":"

S\u00fcdamepuudulikkus on t\u00f5sine seisund, mil s\u00fcda ei suuda pumbata piisavalt verd kehas laiali.<\/p>\n

S\u00fcdamepuudulikkus m\u00f5jutab miljoneid inimesi kogu maailmas. Hinnanguliselt on ainu\u00fcksi USA-s \u00fcle 6 miljoni inimesel<\/a> krooniline s\u00fcdamepuudulikkus.<\/p>\n

S\u00fcdamepuudulikkus m\u00f5jutab oluliselt elukvaliteeti, kuid on sageli ka fataalne. S\u00fcdamepuudulikkust v\u00f5ib esineda igas vanuses, see v\u00f5ib tekkida j\u00e4rk-j\u00e4rgult aja jooksul v\u00f5i ootamatult. P\u00f5hjuseks v\u00f5ib olla k\u00f5rge verer\u00f5hk, k\u00f5rge kolesteroolitase, diabeet v\u00f5i muu faktor.<\/p>\n

Kui s\u00fcdamepuudulikkuse traditsioonilised ravimeetodid keskenduvad s\u00fcmptomite leevendamisele, siis Chicago Meditsiini\u00fclikooli hiljutine uuring loob v\u00e4ljavaate t\u00f5husamale ravile. 2023. aasta m\u00e4rtsis avaldati uuring, kus teadlastel \u00f5nnestus olulisel m\u00e4\u00e4ral v\u00e4hendada s\u00fcdameataki ja insuldi riski raske<\/a> s\u00fcdamepuudulikkusega patsientidel.<\/p>\n

See on seni suurim kliiniline uuring, kus s\u00fcdamepuudulikkusega patsiente raviti t\u00fcvirakkudega. Tulemused n\u00e4itavad, et t\u00fcvirakuteraapia v\u00f5ib oluliselt parandada s\u00fcdamefunktsiooni ja s\u00fcdamepuudulikkuse all kannatavate inimeste elukvaliteeti.<\/p>\n

S\u00fcdameinfarkti v\u00f5i insuldi v\u00e4henemine kuni 75%.<\/strong><\/h3>\n

Infarkti ja insuldi tekkes m\u00e4ngib rolli verer\u00f5hk. Verer\u00f5hu kontrollimiseks kasutatakse praegu mitmeid erinevaid ravimeid ja elustiili muutmist, nagu suitsetamisest loobumine ja regulaarne treenimine. Need ravimeetodid aitavad v\u00e4hendada s\u00fcmptomeid, kuid ei paku v\u00e4ljaravimise v\u00f5imalust.<\/p>\n

Aastatel 2014\u20132019 viidi Chicago \u00fclikoolis l\u00e4bi uuring, mis h\u00f5lmas 565 s\u00fcdamepuudulikkusega patsienti vanuses 18\u201380, kellel s\u00fcdamelihased olid n\u00f5rgenenud. Patsiendid jagati juhusliku valiku alusel kahte r\u00fchma: \u00fcks r\u00fchm sai ravi t\u00fcvirakkudega ja teine grupp platseebot. Uuringus osales 51 keskust P\u00f5hja-Ameerikas.<\/p>\n

T\u00fcvirakuteraapia grupis manustati patsientidele kateetri kaudu s\u00fcdamesse ligikaudu 150 miljonit mesenh\u00fcmaalset t\u00fcvirakku (MSC). Need rakud saadi kolme terve noore t\u00e4iskasvanud doonori luu\u00fcdist. Seej\u00e4rel j\u00e4lgiti patsiente kolm aastat s\u00fcdameprobleemide v\u00f5i eluohtlike ar\u00fctmiate suhtes.<\/p>\n

Uuring n\u00e4itas, et aasta jooksul paranes patsientidel s\u00fcdame vasaku vatsakese t\u00f6\u00f6 (vasak vatsake pumpab hapnikurikast verd organismi). Vatsakese j\u00f5udluse suurenemise v\u00e4\u00e4rtus oli statistiliselt oluline. Patsientide \u00fcldine s\u00fcdameinfarkti v\u00f5i insuldi risk v\u00e4henes 58%. Neila aga, kellel oli eelenvalt k\u00f5rge p\u00f5letikutase, v\u00e4henes risk isegi kuni 75%.<\/p>\n

Uuringu autor, doktor Emerson Perin selgitas, et kui viia t\u00fcvirakud p\u00f5letikulisse s\u00fcdamesse, aktiveeruvad sellised rakud, mis eritavad p\u00f5letikuvastaseid aineid, interleukiine. Ravitoime kestuseks oli keskmiselt 30 kuud – seda v\u00f5ib lugeda pikaajaliseks ravitoimeks v\u00f5rreldes teiste ravimeetoditega.<\/p>\n

T\u00fcvirakuravi positiivsed tulemused<\/strong><\/h3>\n

Uuring on suur samm edasi s\u00fcdamepuudulikkuse ravis. See viitab sellele, et t\u00fcvirakuteraapia koos s\u00fcdamepuudulikkuse ravimitega, v\u00f5ib olla ohutu ja kasulik meetod, et v\u00e4hendada surmajuhte antud seisundi korral.<\/p>\n

Erilisi erinevusi k\u00f5rvaln\u00e4htude esinemises kahe grupi vahel ei leitud. Olulisi ohutusprobleeme ei olnud.<\/p>\n

Vaadates s\u00fcdamepuudulikkuse ravi tulevikku, \u00fctleb doktor Perin: “Meil on uus “relv” s\u00fcdamepuudulikkuse vastu ja see uuring avab t\u00f5eliselt ukse, et sinnani j\u00f5uda.”<\/p>\n

Antud uuring n\u00e4itas, et t\u00fcvirakuteraapia on oluline osa uuest “s\u00fcdamepuudulikkusevastasest relvast”. Kliinilisi uuringuid t\u00fcvirakkude m\u00f5just s\u00fcdameinfarkti, insuldi ja muude \u00e4kkjuhtude tuleks teha veel lisaks.<\/p>\n","protected":false},"excerpt":{"rendered":"

S\u00fcdamepuudulikkus on t\u00f5sine seisund, mil s\u00fcda ei suuda pumbata piisavalt verd kehas laiali. S\u00fcdamepuudulikkus m\u00f5jutab miljoneid inimesi kogu maailmas. Hinnanguliselt on ainu\u00fcksi USA-s \u00fcle 6 miljoni inimesel krooniline s\u00fcdamepuudulikkus. S\u00fcdamepuudulikkus m\u00f5jutab oluliselt elukvaliteeti, kuid on sageli ka fataalne. S\u00fcdamepuudulikkust v\u00f5ib esineda igas vanuses, see v\u00f5ib tekkida j\u00e4rk-j\u00e4rgult aja jooksul v\u00f5i ootamatult. P\u00f5hjuseks v\u00f5ib olla k\u00f5rge […]<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-32275","post","type-post","status-publish","format-standard","hentry","category-clinical-updates"],"acf":[],"yoast_head":"\nT\u00fcvirakud s\u00fcdamepuudulikkuse ravis - Future Health Biobank Eesti<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/futurehealthbiobank.com\/ee\/2023\/08\/21\/tuvirakud-sudamepuudulikkuse-ravis\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T\u00fcvirakud s\u00fcdamepuudulikkuse ravis\" \/>\n<meta property=\"og:description\" content=\"S\u00fcdamepuudulikkus on t\u00f5sine seisund, mil s\u00fcda ei suuda pumbata piisavalt verd kehas laiali. S\u00fcdamepuudulikkus m\u00f5jutab miljoneid inimesi kogu maailmas. Hinnanguliselt on ainu\u00fcksi USA-s \u00fcle 6 miljoni inimesel krooniline s\u00fcdamepuudulikkus. S\u00fcdamepuudulikkus m\u00f5jutab oluliselt elukvaliteeti, kuid on sageli ka fataalne. S\u00fcdamepuudulikkust v\u00f5ib esineda igas vanuses, see v\u00f5ib tekkida j\u00e4rk-j\u00e4rgult aja jooksul v\u00f5i ootamatult. 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