{"id":9376,"date":"2019-03-13T16:36:18","date_gmt":"2019-03-13T14:36:18","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/lv\/?p=9376"},"modified":"2019-09-19T16:37:03","modified_gmt":"2019-09-19T13:37:03","slug":"personalizeta-cilmes-sunu-terapija-muguras-smadzenu-traumas-gadijuma","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/lv\/blog\/personalizeta-cilmes-sunu-terapija-muguras-smadzenu-traumas-gadijuma\/","title":{"rendered":"Personaliz\u0113ta cilmes \u0161\u016bnu terapija muguras smadze\u0146u traumas gad\u012bjum\u0101"},"content":{"rendered":"

I\/II f\u0101zes kl\u012bniskie p\u0113t\u012bjumi ir izv\u0113rt\u0113ju\u0161i cilmes \u0161\u016bnu terapijas labv\u0113l\u012bgo ietekmi uz hronisko parapl\u0113\u0123iju (muguras smadze\u0146u trauma), izmantojot medikamentus, kas veidoti no pacientu cilmes \u0161\u016bn\u0101m.<\/h3>\n

<\/p>\n

Izm\u0113\u0123in\u0101jumi tika test\u0113ti Madrid\u0113, Puerta de Hierro slimn\u012bc\u0101 uz 12 pacientiem, izmantojot jauno Dr. J\u0113zus Valleho veidoto NC1 medikamentu. Pacientiem tika ievad\u012btas NC1 devas, kas veidotas no autolog\u0101s mezenhim\u0101l\u0101ss stromas \u0161\u016bnas (MC\u0160) un autolog\u0101s plazmas. Izm\u0113\u0123in\u0101juma m\u0113r\u0137is bija nodro\u0161in\u0101t katram pacientam individu\u0101la tipa terapiju, izmantojot vi\u0146u pa\u0161u cilmes \u0161\u016bnas un izv\u0113rt\u0113jot muguras smadze\u0146u traumas r\u0101d\u012bt\u0101jus ar MRI sken\u0113\u0161anas pal\u012bdz\u012bbu. MRI noteica NC1 devas apjomu katram pacientam.<\/p>\n

Pirms NC1 transplant\u0101cijas, tika iev\u0101kti perif\u0113ro asi\u0146u paraugi no katra pacienta, lai izsl\u0113gtu hromosomu anom\u0101liju iesp\u0113jas, kas var\u0113tu ietekm\u0113t cilmes \u0161\u016bnu izple\u0161anos. MC\u0160 tika ekstrah\u0113tas no pacientiem, apstr\u0101d\u0101tas, savienotas ar asins plazmu un visbeidzot injic\u0113tas muguras smadzen\u0113s. Papildu MC\u0160 devas ievad\u012btas p\u0113c 3 m\u0113ne\u0161iem, savuk\u0101rt rezult\u0101ti tika izv\u0113rt\u0113ti 3, 6, 9 un 12 m\u0113ne\u0161u laik\u0101 p\u0113c oper\u0101cijas.<\/p>\n

Viens no kl\u012bnisko izmekl\u0113jumu dal\u012bbniekiem bija D\u0101vids Serrano, kas cieta no muguras smadze\u0146u traumas pirms 17 gadiem, k\u0101 rezult\u0101t\u0101 vi\u0146\u0161 non\u0101ca rati\u0146kr\u0113sl\u0101. P\u0113c dal\u012bbas pirmaj\u0101 \u0101rst\u0113\u0161anas f\u0101z\u0113, D\u0101vids s\u0101ka iev\u0113rot asinsrites uzlabojumus un jut\u012bbu k\u0101j\u0101s. P\u0113c 12 m\u0113ne\u0161iem vi\u0146\u0161 jau var\u0113ja staig\u0101t un pat braukt ar riteni.<\/p>\n

D\u0101vida gad\u012bjums bija \u012bpa\u0161s, tom\u0113r visi 12 pacienti piedz\u012bvoja visp\u0101r\u012bgus jut\u012bguma uzlabojumus. Rezult\u0101ti liecin\u0101ja, ka vair\u0101k par 50% pacientu uzr\u0101d\u012bja lab\u0101kus motorisk\u0101s aktivit\u0101tes r\u0101d\u012bt\u0101jus, spazmu samazin\u0101\u0161anos un seksu\u0101l\u0101s funkcijas uzlabo\u0161anos. P\u0113tnieki secin\u0101ja, ka \u0161ie rezult\u0101ti ir atkar\u012bgi no cilmes \u0161\u016bnu devas un nav atkar\u012bgi no muguras smadze\u0146u traumas smaguma pak\u0101pes.<\/p>\n

P\u0113c \u0161\u012b veiksm\u012bg\u0101 kl\u012bnisk\u0101 izm\u0113\u0123in\u0101juma beig\u0101m, Puerta de Hierro slimn\u012bca izzi\u0146oja NC1 medikamenta apstiprin\u0101\u0161anu no Sp\u0101nijas z\u0101\u013cu a\u0123ent\u016bras puses. Tika nor\u0101d\u012bts, ka, lai uzs\u0101ktu \u0101rst\u0113\u0161anu, pacientam ir j\u0101b\u016bt pieaugu\u0161ajam vecum\u0101 no 18-65 gadiem ar hroniskas muguras smadze\u0146u traumas diagnozi bez hromosomu izmai\u0146\u0101m.<\/p>\n

Huans Karvajals, pacients, kas cieta no parapl\u0113\u0123ijas, uzmundrina katru, kas dom\u0101 par terapijas uzs\u0101k\u0161anu:<\/p>\n

Es teiktu tiem pacientiem ne\u0161aub\u012bties par \u0161o izv\u0113li, nedom\u0101t par to, neatlikt uz v\u0113l\u0101ku laiku, \u0101rst\u0113\u0161ana tiek veikta, izmantojot m\u016bsu pa\u0161u cilmes \u0161\u016bnas, t\u0101p\u0113c to noraide nav iesp\u0113jama un rezult\u0101ts ir acumirkl\u012bgs, uzlabojumiem, un \u0161ie uzlabojumi ir fiziski. M\u0113s esam non\u0101ku\u0161i lab\u0101s rok\u0101s gan ment\u0101li, gan mor\u0101li.<\/p><\/blockquote>\n

– Huans Karvajals, muguras smadze\u0146u traumas pacients<\/cite><\/p>\n

Atsauces:
\nwww.sciencedirect.com\/<\/strong><\/a>
\nwww.tellerreport.com\/<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

I\/II f\u0101zes kl\u012bniskie p\u0113t\u012bjumi ir izv\u0113rt\u0113ju\u0161i cilmes \u0161\u016bnu terapijas labv\u0113l\u012bgo ietekmi uz hronisko parapl\u0113\u0123iju (muguras smadze\u0146u trauma), izmantojot medikamentus, kas veidoti no pacientu cilmes \u0161\u016bn\u0101m.<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9376","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nPersonaliz\u0113ta cilmes \u0161\u016bnu terapija muguras smadze\u0146u traumas gad\u012bjum\u0101 | Future Health Biobank<\/title>\n<meta name=\"description\" content=\"I\/II f\u0101zes kl\u012bniskie p\u0113t\u012bjumi ir izv\u0113rt\u0113ju\u0161i cilmes \u0161\u016bnu terapijas labv\u0113l\u012bgo ietekmi uz hronisko parapl\u0113\u0123iju 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