{"id":976,"date":"2014-03-21T10:01:11","date_gmt":"2014-03-21T09:01:11","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/rs\/?p=976"},"modified":"2016-08-10T10:34:25","modified_gmt":"2016-08-10T08:34:25","slug":"upotreba-maticnih-celija-iz-pupcane-vrpce-kod-fankonijeve-anemije","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/rs\/blog\/upotreba-maticnih-celija-iz-pupcane-vrpce-kod-fankonijeve-anemije\/","title":{"rendered":"Upotreba mati\u010dnih \u0107elija iz pup\u010dane vrpce kod Fankonijeve anemije"},"content":{"rendered":"<p>Fankonijeva anemija je autozomno recesivno oboljenje sa simptomima koji uklju\u010duju propadanje ko\u0161tane sr\u017ei, predispoziciju za neoplazije,visoku incidencu mielodisplasie, progresivnu pancitopeniju kao i nonhematopoieti\u010dne anomalije u razvoju. Transplantacija mati\u010dnim \u0107elijama je jedini tretman za ovo stanje. Najbolji rezultati su postignuti kada je kori\u0161\u0107en uzorak brata ili sestre. Ako ne postoji kompatibilan uzorak brata\/ sestre, mo\u017ee da se koristi i uzorak nepoznatog donora, ali rezultati su slabiji i postoji visoka mogu\u0107nost morbiditeta i mortaliteta\u00b9.<\/p>\n<p> <!--more--><\/p>\n<p>Prva uspe\u0161na upotreba krvi pup\u010dane vrpce za le\u010denje te\u0161kog oblika Fankonijeve anemije je obavljena 1988 u Parizu i izvr\u0161ila ga je Eliane Gluckman u saradnji sa Hal Brokmeier.\u00b2<\/p>\n<p>Jedan od najnovijih uspe\u0161nih upotreba mati\u010dnih \u0107elija hematopoeze za le\u010denje pacijenta sa Fankonijevom Anemijom se dogodio u Jordanu u 2012. Pacijent je bio 16 godina star mladi\u0107. Njegova mla\u0111a sestra je ro\u0111ena 2010. Pup\u010dana krv njegove sestre je bila sakupljena odmah posle ro\u0111enja, obra\u0111ena i krioprezervirana u Future Health Biobank. Bila je HLA podudarna sa njenim bratom. Po\u0161to je ovaj uzorak bio dostupan nije bilo neophodno da se izvr\u0161i prikupljanje ko\u0161tane sr\u017ei devoj\u010dice u cilju obavljanja postupka.<\/p>\n<p>Procedura je izvedena na Institutu za onkologiju \u2019\u2019 Kralj Husein\u2019\u2019 u Jordanu u maju 2012. Uzorak krioprezervirane krvi pup\u010dane je otopljen i zatim dat kao infuzija bez dodatne obrade.<\/p>\n<p>Pacijent nije imao ozbiljnih komplikacija. On je kasnije pu\u0161ten iz bolnice. Danas, 20 meseci posle transplantacije pacijent nema graft protiv doma\u0107ina bolesti i vodi normalan \u017eivot .   Od 1988 se procenjuje da je vi\u0161e od 30.000 transplantacija pup\u010dane krvi izvr\u0161eno \u0161irom sveta. \u0160irok spektar anemija, uklju\u010duju\u0107i Fankonijevu, se uspe\u0161no le\u010di.<\/p>\n<p>Reference: (1) Successful umbilical cord blood transplantation for Fanconi anemia using preimplantation genetic diagnosis for HLA-matched donor. Bielorai B, Hughes MR, Auerbach AD, Nagler A, Loewenthal R, Rechavi G, Toren A. American Journal of Hematology, 2004 Dec;77(4):397-9. (2) Gluckman E, Broxmeyer HE, Auerbach AD, Freidman HS, Douglas GW, Devergie A, Esperou H, Thierry D, Socie G, Lehn P, Cooper S, English D, Kurtzberg J, Bard J, Boyse EA. N Engl J Med 1989;321:11741178 <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fankonijeva anemija je autozomno recesivno oboljenje sa simptomima koji uklju\u010duju propadanje ko\u0161tane sr\u017ei, predispoziciju za neoplazije,visoku incidencu mielodisplasie, progresivnu pancitopeniju kao i nonhematopoieti\u010dne anomalije u razvoju. Transplantacija mati\u010dnim \u0107elijama je jedini tretman za ovo stanje. Najbolji rezultati su postignuti kada je kori\u0161\u0107en uzorak brata ili sestre. Ako ne postoji kompatibilan uzorak brata\/ sestre, mo\u017ee da [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-976","post","type-post","status-publish","format-standard","hentry","category-uncategorised"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.7 (Yoast SEO v26.7) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Upotreba mati\u010dnih \u0107elija iz pup\u010dane vrpce kod Fankonijeve anemije - Future Health Biobank Serbia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/futurehealthbiobank.com\/rs\/blog\/upotreba-maticnih-celija-iz-pupcane-vrpce-kod-fankonijeve-anemije\/\" \/>\n<meta property=\"og:locale\" content=\"sr_RS\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Upotreba mati\u010dnih \u0107elija iz pup\u010dane vrpce kod Fankonijeve anemije\" \/>\n<meta property=\"og:description\" content=\"Fankonijeva anemija je autozomno recesivno oboljenje sa simptomima koji uklju\u010duju propadanje ko\u0161tane sr\u017ei, predispoziciju za neoplazije,visoku incidencu mielodisplasie, progresivnu pancitopeniju kao i nonhematopoieti\u010dne anomalije u razvoju. 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