{"id":10139,"date":"2019-01-21T13:53:57","date_gmt":"2019-01-21T13:53:57","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/ua\/?p=10139"},"modified":"2019-08-01T13:54:26","modified_gmt":"2019-08-01T12:54:26","slug":"cilmes-sunas-veic-apversienu-ms-saskana-ar-jaunajiem-novatoriskajiem-petijumiem","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/ua\/blog\/cilmes-sunas-veic-apversienu-ms-saskana-ar-jaunajiem-novatoriskajiem-petijumiem\/","title":{"rendered":"Cilmes \u0161\u016bnas veic apv\u0113rsienu MS saska\u0146\u0101 ar jaunajiem novatoriskajiem p\u0113t\u012bjumiem"},"content":{"rendered":"

Nelieli kl\u012bniski p\u0113t\u012bjumi ir par\u0101d\u012bju\u0161i, ka liel\u0101kajai da\u013cai ar sklerozi slimojo\u0161u pacientu, sa\u0146emot cilmes \u0161\u016bnu transplant\u0101tu kop\u0101 ar \u0137\u012bmijterapiju, tika nov\u0113roti dz\u012bves kvalit\u0101tes uzlabojumi.<\/h3>\n

<\/p>\n

Aizraujo\u0161ais jaunais p\u0113t\u012bjums tika public\u0113ts \u0161om\u0113ness un taj\u0101 piedal\u012bj\u0101s 110 pacientu ar recidiv\u0113jo\u0161u remit\u0113jo\u0161u multiplo sklerozi 11 gadu laikposm\u0101. P\u0113t\u012bjumus veica sal\u012bdzin\u0101jumu div\u0101s grup\u0101s: vienai tika noteikta standarta slim\u012bbu modific\u0113jo\u0161a \u0101rst\u0113\u0161ana (DMT); otrai pied\u0101v\u0101ts asinsrado\u0161o defic\u012bta cilmes \u0161\u016bnu transplant\u0101ts (HSCT) kop\u0101 ar \u0137\u012bmijterapiju.<\/p>\n

P\u0113c izv\u0113rt\u0113\u0161anas no 1 l\u012bdz 5 gadu laikposm\u0101 p\u0113tnieki noskaidroja, ka 34 pacientiem no DMT grupas tika nov\u0113rota slim\u012bbas progres\u0113\u0161ana sal\u012bdzin\u0101jum\u0101 ar tikai 3 pacientiem HSCT grup\u0101. Pirmaj\u0101 gad\u0101 p\u0113c EDSS skalas (papla\u0161in\u0101t\u0101s invalidit\u0101tes statusa skala) tika nov\u0113roti uzlabojumi ar\u012b HSCT grup\u0101, tikm\u0113r tas pasliktin\u0101j\u0101s DMT grup\u0101.<\/p>\n

Vienai p\u0113t\u012bjuma dal\u012bbniecei, 28 gadus vecajai Amandai Lojai (Amanda Loy), tika pied\u0101v\u0101ts cilmes \u0161\u016bnu transplant\u0101ts:<\/p>\n

Tas izklaus\u0101s tik dramatiski, bet [\u0101rst\u0113\u0161ana] atgrieza mani pie dz\u012bves\u2026 Es nebiju gaid\u012bjusi t\u0101dus uzlabojumus. \u013baujoties tam, es pie sevis nodom\u0101ju, \u201cJa vien tas nenodar\u012bs man slikt\u0101k, viss b\u016bs k\u0101rt\u012bb\u0101.\u201d T\u0101d\u0113j\u0101di visi uzlabojumi bija absol\u016bti negaid\u012bti, un piln\u012bgi noteikti viens jauks p\u0101rsteigums.<\/p><\/blockquote>\n

Pirms transplant\u0101ta Amanda cieta no multipl\u0101s sklerozes. Vi\u0146a nesp\u0113ja veikt pilna laika darbu, cieta no ur\u012bnp\u016b\u0161\u013ca probl\u0113m\u0101m un bija spiesta lietot kru\u0137us, lai staig\u0101tu. Tom\u0113r p\u0113c tikai viena gada no transplant\u0101ta lieto\u0161anas br\u012b\u017ea, izmantojot vi\u0146as pa\u0161as asins cilmes \u0161\u016bnas, vi\u0146a paman\u012bja p\u0101rsteidzo\u0161as izmai\u0146as. Vi\u0146ai vairs nebija probl\u0113mu ar ur\u012bnp\u016bsli, noguruma, nejut\u012bguma ekstremit\u0101t\u0113s, karstuma nepanesam\u012bbas vai nervu s\u0101pju.<\/p>\n

11 gadu laik\u0101 Amandas MS \u0101rst\u0113\u0161ana progres\u0113ja tik \u013coti, ka nu vi\u0146a atkal str\u0101d\u0101 pilna laika darbu skolot\u0101jas amat\u0101 ASV. Vi\u0146a pat ir sp\u0113j\u012bga nodarboties ar sportu un neizj\u016bt nepiecie\u0161am\u012bbu p\u0113c MS medikamentiem.<\/p>\n

Tas ir lab\u0101kais pier\u0101d\u012bjums cilnu \u0161\u016bnu transplant\u0101ta sal\u012bdzin\u0101\u0161anai ar parasto \u0101rst\u0113\u0161anu\u2026 Tas ir viens no pirmajiem pier\u0101d\u012bjumiem tam, ka pacientiem ar agres\u012bvu MS ir nov\u0113rojami b\u016btisk\u0101ki uzlabojumi p\u0113c transplant\u0101ta lieto\u0161anas nek\u0101 veicot standarta \u0101rst\u0113\u0161anu.<\/p><\/blockquote>\n

– Harijs Atkins (Harry Atkin), cilmes \u0161\u016bnu transplant\u0101tu fizi\u0137is, Ottavas hospit\u0101lis<\/cite><\/p>\n

Bez \u0161aub\u0101m \u0161\u012b pirm\u0101 kl\u012bnisk\u0101 p\u0113t\u012bjuma rezult\u0101ti ir iespaid\u012bgi. Tom\u0113r p\u0113t\u012bjumiem ir ar\u012b savi ierobe\u017eojumi, jo uzlabojumi ir pier\u0101d\u012bti tikai pacientiem ar maz\u0101k tradicion\u0101lu recidiv\u0113jo\u0161i remit\u0113jo\u0161u MS. Turpm\u0101kie izmekl\u0113jumi un kl\u012bniskie p\u0113t\u012bjumi b\u016bs nepiecie\u0161ami, lai dotu iesp\u0113jas pla\u0161\u0101k izplat\u012btiem cilmes \u0161\u016bnu transplant\u0101tiem ar m\u0113r\u0137i \u0101rst\u0113t multiplo sklerozi.<\/p>\n

Atsauksmes:
\njamanetwork.com\/<\/strong><\/a>
\nwww.vox.com\/<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Nelieli kl\u012bniski p\u0113t\u012bjumi ir par\u0101d\u012bju\u0161i, ka liel\u0101kajai da\u013cai ar sklerozi slimojo\u0161u pacientu, sa\u0146emot cilmes \u0161\u016bnu transplant\u0101tu kop\u0101 ar \u0137\u012bmijterapiju, tika nov\u0113roti dz\u012bves kvalit\u0101tes uzlabojumi.<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[218],"tags":[],"class_list":["post-10139","post","type-post","status-publish","format-standard","hentry","category-clinical-update"],"acf":[],"yoast_head":"\nCilmes \u0161\u016bnas veic apv\u0113rsienu MS saska\u0146\u0101 ar jaunajiem novatoriskajiem p\u0113t\u012bjumiem | Future Health Biobank<\/title>\n<meta name=\"description\" content=\"Nelieli kl\u012bniski p\u0113t\u012bjumi ir par\u0101d\u012bju\u0161i, ka liel\u0101kajai da\u013cai ar sklerozi slimojo\u0161u pacientu, sa\u0146emot 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