{"id":30141,"date":"2022-05-17T09:53:03","date_gmt":"2022-05-17T08:53:03","guid":{"rendered":"https:\/\/futurehealthbiobank.com\/vn\/?p=30141"},"modified":"2022-05-17T09:53:03","modified_gmt":"2022-05-17T08:53:03","slug":"thu-nghiem-dot-pha-trong-viec-su-dung-te-bao-goc-ho-tro-dieu-tri-benh-tram-cam-dang-duoc-tien-hanh","status":"publish","type":"post","link":"https:\/\/futurehealthbiobank.com\/vn\/blog\/thu-nghiem-dot-pha-trong-viec-su-dung-te-bao-goc-ho-tro-dieu-tri-benh-tram-cam-dang-duoc-tien-hanh\/","title":{"rendered":"Th\u1eed nghi\u1ec7m \u0111\u1ed9t ph\u00e1 trong vi\u1ec7c s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tr\u1ea7m c\u1ea3m \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh"},"content":{"rendered":"

Ng\u01b0\u1eddi ta \u01b0\u1edbc t\u00ednh r\u1eb1ng c\u1ee9 10 ng\u01b0\u1eddi th\u00ec c\u00f3 01 ng\u01b0\u1eddi s\u1ebd b\u1ecb tr\u1ea7m c\u1ea3m v\u00e0o m\u1ed9t th\u1eddi \u0111i\u1ec3m n\u00e0o \u0111\u00f3 trong cu\u1ed9c \u0111\u1eddi c\u1ee7a h\u1ecd. Tr\u1ea7m c\u1ea3m l\u00e0 tr\u1ea1ng th\u00e1i ph\u1ed5 bi\u1ebfn, \u0111\u1eb7c bi\u1ec7t \u1edf nh\u1eefng ng\u01b0\u1eddi m\u1eafc c\u00e1c b\u1ec7nh kh\u00e1c nh\u01b0 ung th\u01b0, Parkinson v\u00e0 ti\u1ec3u \u0111\u01b0\u1eddng.<\/h3>\n

<\/p>\n

Nguy\u00ean nh\u00e2n ch\u00ednh c\u1ee7a b\u1ec7nh tr\u1ea7m c\u1ea3m v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c hi\u1ec3u bi\u1ebft \u0111\u1ea7y \u0111\u1ee7. Ng\u01b0\u1eddi ta cho r\u1eb1ng t\u00ecnh tr\u1ea1ng n\u00e0y x\u1ea3y ra do s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a c\u00e1c s\u1ef1 c\u1ed1 c\u0103ng th\u1eb3ng trong cu\u1ed9c s\u1ed1ng, di truy\u1ec1n v\u00e0 s\u1ef1 m\u1ea5t c\u00e2n b\u1eb1ng c\u00e1c ch\u1ea5t h\u00f3a h\u1ecdc t\u1ea1o t\u00e2m tr\u1ea1ng nh\u01b0 serotonin trong n\u00e3o.<\/p>\n

Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u1ea5t \u0111\u1ec3 gi\u1ea3i quy\u1ebft t\u00ecnh tr\u1ea1ng m\u1ea5t c\u00e2n b\u1eb1ng h\u00f3a h\u1ecdc nh\u01b0 v\u1eady. Tuy nhi\u00ean, l\u00fd thuy\u1ebft v\u1ec1 s\u1ef1 m\u1ea5t c\u00e2n b\u1eb1ng h\u00f3a h\u1ecdc n\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c ch\u1ee9ng minh v\u00e0 thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ch\u1ec9 l\u00e0 m\u1ed9t bi\u1ec7n ph\u00e1p can thi\u1ec7p ng\u1eafn h\u1ea1n cho b\u1ec7nh tr\u1ea7m c\u1ea3m, kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb l\u00e2u d\u00e0i.<\/p>\n

\u0110\u1ec3 th\u00fac \u0111\u1ea9y c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 tr\u1ea7m c\u1ea3m , c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u trong m\u1ed9t th\u1eed nghi\u1ec7m t\u1ebf b\u00e0o g\u1ed1c m\u1edbi cho b\u1ec7nh tr\u1ea7m c\u1ea3m \u0111ang \u0111\u00e1nh gi\u00e1 t\u00ednh hi\u1ec7u qu\u1ea3 c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c t\u1eeb t\u1ee7y r\u0103ng nh\u01b0 m\u1ed9t c\u00e1ch \u0111\u1ec3 thay \u0111\u1ed5i v\u00e0 c\u1ea3i thi\u1ec7n s\u1ee9c kh\u1ecfe t\u00e2m th\u1ea7n.<\/p>\n

Thay v\u00ec tr\u1ea7m c\u1ea3m l\u00e0 k\u1ebft qu\u1ea3 c\u1ee7a nh\u1eefng bi\u1ebfn c\u1ed1 kh\u00f3 kh\u0103n trong cu\u1ed9c s\u1ed1ng v\u00e0 di truy\u1ec1n, ni\u1ec1m tin m\u1edbi cho r\u1eb1ng s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o th\u1ea7n kinh v\u00e0 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c ki\u1ec3m so\u00e1t t\u00e2m tr\u1ea1ng v\u00e0 c\u1ea3m x\u00fac.<\/p>\n

Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tr\u1ea7m c\u1ea3m d\u1ef1a tr\u00ean nh\u1eefng ph\u00e1t hi\u1ec7n \u0111\u1ed9t ph\u00e1 t\u1eeb \u0110\u1ea1i h\u1ecdc Johns Hopkins cho th\u1ea5y c\u00e1ch m\u00e0 thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o g\u1ed1c trong n\u00e3o \u0111\u1ec3 t\u1ea1o ra c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh m\u1edbi. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u tin r\u1eb1ng c\u00e0ng c\u00f3 nhi\u1ec1u t\u1ebf b\u00e0o th\u1ea7n kinh, giao ti\u1ebfp c\u00e0ng t\u1ed1t h\u01a1n trong c\u00e1c v\u00f9ng n\u00e3o c\u00f3 ch\u1ee9c n\u0103ng ki\u1ec3m so\u00e1t c\u1ea3m x\u00fac.<\/p>\n

Ph\u00e1t tri\u1ec3n c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh m\u1edbi \u0111\u1ec3 ph\u1ee5c h\u1ed3i b\u1ed9 n\u00e3o b\u1ecb tr\u1ea7m c\u1ea3m<\/strong><\/p>\n

Trong th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c ch\u01b0a t\u1eebng c\u00f3 \u0111\u1ed1i v\u1edbi b\u1ec7nh tr\u1ea7m c\u1ea3m n\u00e0y, 48 ng\u01b0\u1eddi \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n m\u1eafc b\u1ec7nh tr\u1ea7m c\u1ea3m s\u1ebd \u0111\u01b0\u1ee3c ti\u1ebfp nh\u1eadn t\u1ebf b\u00e0o g\u1ed1c l\u1ea5y t\u1eeb t\u1ee7y r\u0103ng t\u1eeb ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng.<\/p>\n

T\u1ebf b\u00e0o g\u1ed1c t\u1ee7y r\u0103ng \u0111\u01b0\u1ee3c x\u1eed l\u00fd v\u00e0 l\u00e0m s\u1ea1ch tr\u01b0\u1edbc khi truy\u1ec1n v\u00e0o c\u00e1nh tay c\u1ee7a b\u1ec7nh nh\u00e2n trong b\u1ed1n li\u1ec7u tr\u00ecnh, m\u1ed7i l\u1ea7n c\u00e1ch nhau hai tu\u1ea7n.<\/p>\n

Nh\u1eefng ng\u01b0\u1eddi tham gia nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c truy\u1ec1n t\u1ebf b\u00e0o g\u1ed1c c\u0169ng s\u1ebd \u0111\u01b0\u1ee3c ti\u00eam thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m fluoxetine. Nh\u00f3m \u0111\u1ed1i ch\u1ee9ng c\u1ee7a th\u1eed nghi\u1ec7m s\u1ebd ch\u1ec9 \u0111\u01b0\u1ee3c cung c\u1ea5p fluoxetine h\u00e0ng ng\u00e0y. \u0110i\u1ec1u n\u00e0y cho ph\u00e9p c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111o l\u01b0\u1eddng t\u00e1c \u0111\u1ed9ng c\u1ee7a c\u00e1c t\u1ebf b\u00e0o g\u1ed1c v\u00e0 c\u0169ng c\u00f3 th\u1ec3 th\u1ea5y \u0111\u01b0\u1ee3c c\u00e1ch ch\u00fang t\u01b0\u01a1ng t\u00e1c v\u1edbi thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m.<\/p>\n

Ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u ch\u1ee9ng c\u1ee9 khoa h\u1ecdc \u1ee7ng h\u1ed9 gi\u1ea3 thuy\u1ebft v\u1ec1 s\u1ef1 ph\u00e1t tri\u1ec3n t\u1ebf b\u00e0o th\u1ea7n kinh m\u1edbi trong n\u00e3o c\u00f3 th\u1ec3 gi\u00fap \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng tr\u1ea7m c\u1ea3m.<\/p>\n

C\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng v\u00f9ng h\u1ed3i h\u1ea3i m\u00e3 l\u00e0 v\u00f9ng n\u00e3o li\u00ean quan \u0111\u1ebfn tr\u00ed nh\u1edb v\u00e0 c\u1ea3m x\u00fac nh\u1ecf h\u01a1n \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb tr\u1ea7m c\u1ea3m m\u1ea1n t\u00ednh. \u0110i\u1ec1u n\u00e0y \u1ee7ng h\u1ed9 gi\u1ea3 thuy\u1ebft r\u1eb1ng thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ho\u1ea1t \u0111\u1ed9ng kh\u00f4ng ph\u1ea3i b\u1eb1ng c\u00e1ch th\u00fac \u0111\u1ea9y c\u00e1c ch\u1ea5t h\u00f3a h\u1ecdc trong n\u00e3o nh\u01b0 dopamine v\u00e0 serotonin, m\u00e0 b\u1eb1ng c\u00e1ch h\u1ed7 tr\u1ee3 s\u1ef1 h\u00ecnh th\u00e0nh t\u1ebf b\u00e0o th\u1ea7n kinh m\u1edbi v\u00e0 k\u1ebft n\u1ed1i n\u00e3o.<\/p>\n

C\u0169ng c\u00f3 m\u1ed9t c\u01a1 s\u1edf nghi\u00ean c\u1ee9u l\u1edbn v\u1ec1 m\u1ed1i li\u00ean quan c\u1ee7a tr\u1ea7m c\u1ea3m v\u1edbi ch\u1ee9ng vi\u00eam n\u00e3o. T\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m vi\u00eam trong n\u00e3o v\u00e0 c\u01a1 th\u1ec3, trong tr\u01b0\u1eddng h\u1ee3p tr\u1ea7m c\u1ea3m, c\u00f3 th\u1ec3 h\u00ecnh th\u00e0nh t\u1eeb nhi\u1ec1u n\u0103m c\u0103ng th\u1eb3ng.<\/p>\n

Gi\u00e1o s\u01b0 t\u00e2m th\u1ea7n h\u1ecdc t\u1ea1i \u0110\u1ea1i h\u1ecdc King\u2019s College London Carmine Pariante nh\u1eadn x\u00e9t v\u1ec1 ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn n\u00e0y nh\u01b0 sau:<\/p>\n

\u201cTrong ng\u1eafn h\u1ea1n, c\u0103ng th\u1eb3ng l\u00e0m t\u0103ng s\u1ea3n xu\u1ea5t c\u00e1c ch\u1ea5t h\u00f3a h\u1ecdc trong c\u01a1 th\u1ec3 c\u00f3 \u00edch trong \u0111\u00e1p \u1ee9ng v\u1eadt l\u00fd t\u1ef1 \u0111\u1ed9ng.<\/p>\n

\u201cV\u00ed d\u1ee5, c\u0103ng th\u1eb3ng l\u00e0m t\u0103ng t\u00ecnh tr\u1ea1ng vi\u00eam, gi\u00fap b\u1ea3o v\u1ec7 ch\u00fang ta kh\u1ecfi b\u1ecb nhi\u1ec5m tr\u00f9ng.<\/p>\n

\u201cTuy nhi\u00ean, c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y c\u0103ng th\u1eb3ng t\u00e2m l\u00fd g\u00e2y ra tr\u1ea7m c\u1ea3m – ch\u1eb3ng h\u1ea1n nh\u01b0 th\u1ea5t nghi\u1ec7p, kh\u00f3 kh\u0103n ho\u1eb7c m\u1ea5t m\u00e1t trong h\u00f4n nh\u00e2n – th\u01b0\u1eddng k\u00e9o d\u00e0i v\u00e0 v\u1ec1 l\u00e2u d\u00e0i, t\u00ecnh tr\u1ea1ng vi\u00eam gia t\u0103ng l\u00e0m gi\u1ea3m vi\u1ec7c sinh ra c\u00e1c t\u1ebf b\u00e0o n\u00e3o m\u1edbi v\u00e0 s\u1ef1 k\u1ebft n\u1ed1i gi\u1eefa c\u00e1c t\u1ebf b\u00e0o n\u00e3o, d\u1eabn \u0111\u1ebfn tr\u1ea7m c\u1ea3m. \u201d<\/p>\n

T\u1ebf b\u00e0o g\u1ed1c c\u00f3 nhi\u1ec1u h\u1ee9a h\u1eb9n trong \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m nh\u1edd kh\u1ea3 n\u0103ng kh\u00f4ng ch\u1ec9 t\u1ea1o ra c\u00e1c t\u1ebf b\u00e0o n\u00e3o m\u1edbi m\u00e0 c\u00f2n ti\u1ebfp c\u1eadn c\u00e1c khu v\u1ef1c b\u1ecb \u1ea3nh h\u01b0\u1edfng v\u00e0 gi\u1ea3m t\u00e1c \u0111\u1ed9ng vi\u00eam do c\u0103ng th\u1eb3ng l\u00ean n\u00e3o.<\/p>\n

T\u1ebf b\u00e0o g\u1ed1c \u0111\u01b0\u1ee3c ghi nh\u1eadn r\u1ed9ng r\u00e3i v\u1ec1 l\u1ee3i \u00edch \u0111\u1ed1i v\u1edbi m\u1ed9t lo\u1ea1t v\u1ea5n \u0111\u1ec1 th\u1ec3 ch\u1ea5t. Th\u1eed nghi\u1ec7m t\u1ebf b\u00e0o g\u1ed1c n\u00e0y \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m c\u00f3 th\u1ec3 ch\u1ee9ng minh r\u1eb1ng nh\u1eefng t\u1ebf b\u00e0o t\u1ee7y r\u0103ng \u0111\u00e1ng kinh ng\u1ea1c c\u0169ng \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c c\u1ea3i thi\u1ec7n s\u1ee9c kh\u1ecfe t\u00e2m th\u1ea7n.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ng\u01b0\u1eddi ta \u01b0\u1edbc t\u00ednh r\u1eb1ng c\u1ee9 10 ng\u01b0\u1eddi th\u00ec c\u00f3 01 ng\u01b0\u1eddi s\u1ebd b\u1ecb tr\u1ea7m c\u1ea3m v\u00e0o m\u1ed9t th\u1eddi \u0111i\u1ec3m n\u00e0o \u0111\u00f3 trong cu\u1ed9c \u0111\u1eddi c\u1ee7a h\u1ecd. Tr\u1ea7m c\u1ea3m l\u00e0 tr\u1ea1ng th\u00e1i ph\u1ed5 bi\u1ebfn, \u0111\u1eb7c bi\u1ec7t \u1edf nh\u1eefng ng\u01b0\u1eddi m\u1eafc c\u00e1c b\u1ec7nh kh\u00e1c nh\u01b0 ung th\u01b0, Parkinson v\u00e0 ti\u1ec3u \u0111\u01b0\u1eddng.<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[220],"tags":[],"class_list":["post-30141","post","type-post","status-publish","format-standard","hentry","category-clinical-updates"],"acf":[],"yoast_head":"\nTh\u1eed nghi\u1ec7m \u0111\u1ed9t ph\u00e1 trong vi\u1ec7c s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tr\u1ea7m c\u1ea3m \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh - Future Health Biobank Vietnam<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Th\u1eed nghi\u1ec7m \u0111\u1ed9t ph\u00e1 trong vi\u1ec7c s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tr\u1ea7m c\u1ea3m \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh\" \/>\n<meta property=\"og:description\" content=\"Ng\u01b0\u1eddi ta \u01b0\u1edbc t\u00ednh r\u1eb1ng c\u1ee9 10 ng\u01b0\u1eddi th\u00ec c\u00f3 01 ng\u01b0\u1eddi s\u1ebd b\u1ecb tr\u1ea7m c\u1ea3m v\u00e0o m\u1ed9t th\u1eddi \u0111i\u1ec3m n\u00e0o \u0111\u00f3 trong cu\u1ed9c \u0111\u1eddi c\u1ee7a h\u1ecd. 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